Tissue Mast Cell Leukemia

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Mast Cell Leukemia with Ascites and Multiple Organs Damage

Mast Cell Leukemia (MCL), a rare subtype of systemic mastocytosis is defined by bone marrow involvement as atypical and aleukemic mast cells, if more than 20% and less than 10% of peripheral WBCs are mast cells, respectively. We met a case of aleukemic MCL presenting with anemia and ascites for 2 years, referred for BM evaluation, suspicious of leukemia. Our findings included BM involveme...

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INFLUENCE OF NERVE TISSUE-DERIVED NEUROTRANSMITTERS ON MAST CELL MIGRATION

In vitro culture systems using bone marrow cells from BALB/C mice were set up in medium supplemented with spleen-derived medium. Bone marrow cells grown in spleen-derived medium gave rise to cultures containing >97% mast cells. The cells were used in polarisation chemotaxis assays with the intention of determining the effect of nerve tissue-derived neurotransmitters on mast cell migration. ...

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Mast cell leukemia.

Mast cell leukemia (MCL) is a very rare form of aggressive systemic mastocytosis accounting for < 1% of all mastocytosis. It may appear de novo or secondary to previous mastocytosis and shares more clinicopathologic aspects with systemic mastocytosis than with acute myeloid leukemia. Symptoms of mast cell activation-involvement of the liver, spleen, peritoneum, bones, and marrow-are frequent. D...

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influence of nerve tissue-derived neurotransmitters on mast cell migration

in vitro culture systems using bone marrow cells from balb/c mice were set up in medium supplemented with spleen-derived medium. bone marrow cells grown in spleen-derived medium gave rise to cultures containing >97% mast cells. the cells were used in polarisation chemotaxis assays with the intention of determining the effect of nerve tissue-derived neurotransmitters on mast cell migration. some...

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Aleukemic variant of mast cell leukemia.

A woman was admitted with fatigue, icterus, thrombocytopenia (77 109/L), normocytic anemia (9.8 g/dL), and a normal white blood cell count (8.5 109/L). The peripheral blood smear showed metamyelocytes, myelocytes, monocytes, erythroblasts, and atypical cells with bilobulated nuclei resembling basophil granulocytes (left panel of figure). In the bone marrow there was a nearly complete infiltrati...

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ژورنال

عنوان ژورنال: Blood

سال: 1958

ISSN: 0006-4971,1528-0020

DOI: 10.1182/blood.v13.1.70.70